Increase of survival & immunoresponse enhancement with ElectroChemotherapy in Lung & Colorectal cancer in mural models-2019

admin — Thu, 12 Dec 2019 09:43:07 +0000

Electrochemotherapy

Is an emerging treatment modality for cancer patients which can effectively reduce tumour burden and induce immunogenic cell death. Electrochemotherapy is most commonly used with bleomycin as the drug of choice, here we examine the efficacy of electrochemotherapy with cisplatin. Electrochemotherapy with cisplatin was found to effectively reduce tumour growth in a range of murine models and induce significant intratumoural recruitment of myeloid and humoral immune cells. Following the observations of immune system mobilisation, we have shown an ability of electrochemotherapy to reduce metastatic potential as determined by tumour burden in the lung, and to exert an abscopal effect by reducing growth at distal untreated secondary tumours.

What drugs are being used most in ElectroChemotherapy? Bleomycin & Cisplatin

Highlights

• ECT with cisplatin is an effective form of therapy showing significant decrease in cancer cell growth in vitro and in vivo.•

• Immune cell mobilisation is visible locally and systemically following treatment.•

• ECT with cisplatin may be useful in reducing the growth of distal untreated growth and controlling metastatic disease.

Read the entire article on this LINK

Reference:

Cancer Letters

Volume 442, 1 February 2019, Pages 475-482

WHO warning: E-cigarettes won’t help in reducing cancer

admin — Tue, 20 Aug 2019 09:38:53 +0000

No evidence to justify their claim according to World Health Organization (WHO)

Electronic cigarettes and heated tobacco products are not helping fight cancer, the World Health Organisation (WHO) says, urging smokers and governments not to trust claims from cigarette firms about their latest products.

The seventh “WHO report on the global tobacco epidemic” said blocking the industry’s interference was critical to cutting the harm from tobacco use.

“The tobacco industry has a long history of systemic, aggressive, sustained and well-resourced opposition to tobacco control measures,” the report said.

“While some strategies are public and others more covert, all have the goal of weakening tobacco control.”

The report said tobacco giant Philip Morris International was trying to position itself as a responsible public health partner via its “Unsmoke” campaign, which encourages people to “change to a better alternative”.

The WHO said the campaign aimed to ensure tobacco remained socially acceptable, while confusing consumers with terms such as “smoke-free products”, which may refer to products with toxic emissions and unknown short-term and long-term health effects.

Philip Morris spokesman Ryan Sparrow said the WHO’s message made it harder to provide safer options for people who cannot quit smoking.

“There is no question that the best choice for smokers is to quit cigarettes and nicotine altogether. The reality is many people do not. We cannot turn our backs on them,” he said. “Organisations like the World Health Organisation need to stop talking at smokers and start listening.”

The WHO report said the industry hoped to win respectability through manipulative messages such as claiming their products were part of a “harm reduction” strategy, even though cigarettes still account for 97 per cent of the global tobacco market.

Vinayak Prasad, program manager of WHO’s tobacco control unit, said development of new products was solely intended to expand the markets of tobacco firms.

“There is no difference between cigarettes and heated tobacco products except that in terms of exposure: the exposure is less and the smoke is not visible,” he said.

Electronic cigarettes, containing nicotine but not tobacco, were promoted as a way to quit smoking. But there was no evidence to justify the claim, and evidence from the United States showed they had increased the prevalence of young people smoking, he said.

“So it’s also a gateway for young people,” Prasad said.

“The answer is it needs to be regulated. WHO has clear guidelines – to get electronic cigarettes regulated. And if you are banning it, fine, but if you aren’t banning it don’t let it (go) free in the market, because the young people are taking it up.”